CBDA (Cannabidiolic Acid): Effects, Benefits & More


CBDA (Cannabidiolic Acid) Header

This post is part of a series on cannabis compounds. For more information and a listing of all other cannabinoids, see our Cannabis Compounds overview.

When we discuss non-psychoactive cannabinoids that contain a wide range of health benefits, CBD tends to steal the spotlight. As time passes and investigations into the cannabis plant continue, the acid-form chemical precursor to CBD has begun to show extreme promise. Cannabidiolic Acid also known as CBDA is a naturally occurring phytocannabinoid abundant to high-CBD hemp and marijuana strains.

Cannabidiolic Acid Molecule

Activity: Non-psychoactive
Formula: C22H30O4 
Molecular Mass: 358.2144 g/mol 
Boiling Point: 120+ °C (248 °F)

CBDA vs CBD

As cannabis grows, CBGA biosynthesizes into three main cannabinoids: THCA, CBCA, and CBDA. These molecules are known as 'raw' or 'non-activated' cannabinoids. Not until these molecules undergo a heating process called decarboxylation do they transform into their well-known 'active' forms: THC, CBD, and CBC.

Simply put, CBDA is the parent of CBD.

So why all the fuss about raw cannabinoids like Cannabidiolic Acid? Well, it turns out that these compounds provide unique and synergistic benefits to their heated forms. Specific to CBDA, the great promise and positive initial results have led to a fair amount of initial research on the compound.

The positive signs provided by these studies have been strong enough that many companies are providing either raw extractions or blending these raw extracts with the more common decarboxylated extracts. I.E. raw CBDA formulas, or CBD+CBDA blends. The result is a range of products that provide additional, specific benefits to the user.

What Are the Effects & Benefits of CBDA?

Along with CBD, this raw acid-form does not have psychoactive effects. There are many potential benefits to this compound with studies showing that the molecule has positive effects when taken alone or in combination with other cannabinoids via the entourage effect.

  • Anti-proliferative - prevents cancer cell migration, noted specifically in cases of aggressive breast cancer. (Source)
  • Antiemetic - reduces nausea and vomiting. (Source)
  • Anti-inflammatory and pain reduction through COX-2 inhibition. (Source)
  • Positive effect on seizures for the treatment of epilepsy, also when used in combination with CBD. (Source)
  • Anti-anxiety effects. (Source)
  • Potential anti-depressive effects through  5-HT1A receptor activation. (Source)

Where Can You Find CBDA?

Just like all the other raw cannabinoids, CBDA is found in mature hemp or marijuana that is ready for harvest. Despite this compound being extremely abundant in the plants used to create the CBD-rich products on the market today, finding CBDA can be though. This is because the vast majority of extractors decarboxylate, or heat, the extracted cannabinoids in order to activate them.

While you could simply eat cannabis to ingest this compound, most of the time that isn't a great option. Most companies creating a CBDA-rich product use a low-temperature juicing or extraction process to extract these raw compounds. As an example, hemp would be cold pressed much like a vegetable juice. The resulting liquid/extract is then sold directly or commonly blended with a heated extract.

A blended product containing raw and activated cannabinoids, as opposed to simply activated cannabinoids, has the potential to unlock an even higher level of the entourage effect. This could explain why products containing 1:1 CBDA to CBD are becoming more popular.

As a consumer looking for a CBDA rich product, we suggest looking for brands like Endoca that are focused on providing raw cannabinoid products.


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