An Overview of Minor Cannabinoids

Minor Cannabinoids Header

This post is part of a series on cannabis compounds. For more information and a listing of all other cannabinoids, see our Cannabis Compounds overview.

Cannabinoids, the chemical compounds which interact with the body's endocannabinoid system, uniquely found in cannabis. There are over 100 of these naturally occurring compounds (phytocannabinoids) that produce a wide range of therapeutic benefits. Of these, there are stars like THC and CBD that are well known by many.

The less significant and less researched cannabinoids are not often discussed, but we believe these should be at least mentioned. These compounds are uniquely produced by the cannabis plant, may offer undiscovered benefits that could be applied in future use, and play a role in the entourage effect of cannabis:

CBCA (Cannabichromenic Acid)

CBCA Molecule

Formula: C22H30O4
Molecular Mass: 358.2144 g/mol

This compound is the lesser known of the three compounds biosynthesized by the cannabis plant from CBGA. CBCA is the raw precursor to CBC. When heated via decarboxylation, this compound loses a carbon chain from its molecular structure. This process converts it from its acid form to the activated form. Though research is minimal, Cannabichromenenic Acid is known to possess anti-inflammatory, minor anti-fungal, and strong anti-bacterial function.

CBGVA (Cannabigerovarinic Acid)

CBGVA Molecule

Formula: C20H28O4
Molecular Mass: 332.44 g/mol

Similar to CBGA, CBGVA is the precursor to the propyl cannabinoid acids, signified with the VA suffix. As the cannabis plant matures, this compound synthesizes into THCVA, CBDVA, and CBCVA.

THCVA (Tetrahydrocannabivarinic Acid)

THCVA Molecule

Formula: C20H26O4
Molecular Mass: 330.42 g/mol

Little is known about the effects of this propyl acid other than it is a child of CBGVA. One notable use is testing for the presence of THCVA as a marker for cannabis consumption when compared to the intake of synthetic THC medicines which do not contain this compound.

CBDVA (Cannabidivarinic Acid)

CBDVA Molecule

Formula: C20H26O4
Molecular Mass:  330.42 g/mol

Similar to its sister-compound CBDA, this raw cannabinoid is non-psychoactive derived from CBGVA. Like many minor cannabinoids, it reportedly has anti-inflammatory properties.

CBCVA (Cannabichromevarinic Acid)

CBCVA Molecule

Formula: C20H26O4
Molecular Mass:  330.42 g/mol

CBCVA is the least researched and least abundant of the compounds derived from CBGVA.

CBGV (Cannabigerovarin)

CBGV Molecule

Formula: C19H28O2
Molecular Mass:  288.431 g/mol

CBGV is a non-psychoactive cannabinoid that appears to assist CBD in helping adhere to the body's endocannabinoid receptors. Through this action, this compound provides anticonvulsant effects. It also has been studied to show potential as a cancer-fighting compound, specifically researched in cases of inhibiting the growth of leukemia cells. This compound is produced through decarboxylation of CBGVA.

CBCV (Cannabichromevarin)

CBCV Molecule

Formula: C19H26O2
Molecular Mass:  286.415 g/mol

CBCV is produced through the heating of CBCVA. Because of the similar molecular structure to CBC, CBCV may also have similar effects. Assuming this, CBCV could carry anti-inflammatory, antidepressant, antibiotic, analgesic and antifungal properties.

CBNA (Cannabinolic Acid)

CBNA Molecule

Formula: C22H26O4
Molecular Mass:  354.44 g/mol

CBNA is a non-psychoactive cannabinoid that is produced through the aging process of THCA.

CBLA (Cannabicyclolic Acid)

CBLA Molecule

Formula: C22H30O4
Molecular Mass:  358.478 g/mol

CBLA is produced in very small amounts through the aging of CBCA. This cannabinoid is the most stable of the raw, acid group when it comes to heat. The cannabinoid resists decarboxylation and is instead formed through oxidation. The compound shows anti-inflammatory and anti-tumor uses.

CBL (Cannabicyclol)

CBL Molecule

Formula: C21H30O2
Molecular Mass:  314.469 g/mol

Cannabicyclol is produced through the degradation of CBC through the exposure to light. The compound is non-psychoactive and has been shown to have very little to no known medicinal properties.

Originally Published: September 14, 2018 | Last Updated: September 27, 2018

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