Discover supporting research and information on how cannabidiol (CBD) relates to the treatment of Depression.

Every person experiences fluctuations in mood, sadness, and a lack of pleasure in daily activities from time to time. While these feelings are normal, if they persist for long periods or negatively impact a person's daily life, they may be signs of major depressive disorder. This serious mental illness negatively impacts the way a person thinks and acts resulting in a decrease in the ability to function at home or at work.

Depression is a very common mental illness that results in over 3 million cases in the United States each year. An average of one in six people will experience depression in their lifetime. While depression can occur at any time, it most commonly first appears during late teens to mid-twenties. Women are more likely to experience depression than men and the average depressive bout lasts from 6 to 8 months.

The good news is that depression is treatable through various forms of medication and psychotherapy.


The symptoms exhibited by those who suffer from depression range from mild to severe. Depression is diagnosed when symptoms last for at least two weeks. Symptoms include:


The root cause of depression is varied and often made up of many factors including:

Factors that Increase the Likelihood of Depression


Treating Depression with CBD

Current antidepressant medications display a substantial time lag to induce a therapeutic response. Some medications need to be taken for 1-2 months before full effect can be observed. The extended onset is often followed by a relatively low efficacy. With depression being such a common and major issue in modern society, the development of effective, fast-acting drugs is key.

Studies have long pointed to CBD's potential use as an antidepressant. Recent studies have shown encouraging evidence that CBD exerts fast and maintained antidepressant-like effects thanks to the interaction with 5-HT(1A) receptors in the brain. These findings point to the compounds promising future use as an antidepressant medication.


Most current research is animal-based and does not reference dosages for humans. Standard generalized dosages range from 10-25mg per dose.

For more information, see our dosage guidelines for CBD.

Supporting Research

The contents of this page are not medical advice. Please seek professional medical assistance for any condition and before starting, stoping, or changing medication or supplements.